Anti-VEGF Treatment

This is different for every patient. However, multiple injections are often required for complete inactivation of the disease process.

• Wet age-related macular degeneration (AMD)

• Swelling of the retina called macular edema

• Diabetic Retinopathy

• Retinal Vein Occlusion

a): Avastin (Bevacizumab) is an anti-VEGF agent approved for use in colorectal cancer. Ophthalmologists are using it “off-label” in AMD and other vascular conditions for its anti-angiogenic property. When used in the eye as an intravitreal injection, the dose is extremely small. This makes the risk of adverse systemic reactions like gastrointestinal perforation, thrombo-embolic reactions, hypertension and proteinuria, negligible. The use of Avastin is off- label but recent experience with this drug has been encouraging with most patients getting stabilized and some improvements.

b): Lucentis (Ranibizumab) is a FDA-approved anti-VEGF agent. It is a recombinant homogenized monoclonal antibody. Clinical trials with Lucentis have shown not only stabilization but also the improvement in visual acuity in some patients.

c): Eylea(Aflibercept) is newly launched FDA-approved anti-VEGF agent. It is a long acting drug so requires less frequent injections. This reduces the frequent visits. The potential benefit of this drug has been found in AMD variants like polypoidal vasculopathy.

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• The eye is numbed with topical anaesthesia.

• Your eye is cleaned to prevent infection.

• A small clip like device may be used to keep your eyes open and eyelids out of the way.

• Our retina specialist injects the drug through the white part of your eye using a very thin needle.

• The injection only takes a fraction of the second. You usually do not see the needle itself.

After the injection you can go home. There are some precautions that you have to observe.

The procedure is relatively atraumatic and the needle used is very tiny. However, as with any procedure, it carries a small risk of post-injection infection, raised or low intraocular pressure, cataract formation, vitreous haemorrhage & retinal detachment.

In case you have a recent history of a cardiac problem, uncontrolled hypertension or severe proteinuria, you may be given systemic anti-VEGF agents instead.

Worried? Speak to the best retina eye doctors in Ghaziabad.

Anti-VEGFs stabilise vision in most people. They may also improve vision in one third of the people who receive treatment.

This depends on the cause and severity of your macular degeneration or macular edema. Our eye experts will make this decision. You many need other types of treatment such as laser or surgery.

Sometimes, our cells can produce excessive amounts of VEGF. This happens in some retinal conditions, where abnormal blood vessels begin to grow in the eye. These abnormal vessels can damage our eyes and lead to a loss of vision.